Product NameEthyl 3-oxo-4-phenylbutanoate: | Ethyl 3-oxo-4-phenylbutanoate | CAS: | 718-08-1 |
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EINECS: | 226-500-0 | Chemical Formula: | C12H14O3 |
Density: | 1.091 | Boiling Point: | 290℃ |
Flashing Point: | 124℃ | Vapour Pressure: | 0.00209mmHg At 25°C |
Solubility: | Chloroform (Slightly), DMSO (Slightly), Methanol (Sparingly) | Refractive Index: | 1.054-1.059 |
Appearance: | Transparency Liquid | ||
High Light: | CAS 718-08-1 Ethyl 3-oxo-4-phenylbutanoate BMK Chemical |
Product Name: | Benzenebutanoic acid,b-oxo-,ethyl ester | |
CAS : | 718-08-1 | |
Synonyms: |
3-OXO-4-PHENYL-BUTYRIC ACID ETHYL ESTER;3-keto-4-phenyl-butyric acid ethyl ester;ethyl 3-oxo-4-phenylbutanoate;ethyl 3-oxo-4-phenyl-butanoate;4-Phenyl-3-oxobutanoic acid ethyl ester;Ethyl 4-phenylacetoacetate
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Category: | Heterocyclic Organic Compound |
Molecular Formula: | C12H14O3 |
Molecular Weight: | 260.24 |
Density: | 1.091 |
Boiling Point: | 290°C |
Flash Point: | 124℃ |
Category: | Heterocyclic Organic Compound |
Canonical SMILES: | CCOC(=O)CC(=O)CC1=CC=CC=C1 |
Physical: properties: | Diethyl(phenylacetyl)malonate has a boiling point of 290℃ Its density is predicted to be 1.091. |
Uses: | A useful synthetic intermediate, often used in the preparation of anti-prion compounds and gene expression inhibitors |
Preparation: |
(1) Ethyl acetoacetate and methylene chloride of phenylacetyl chloride were prepared into a mixture in a certain proportion, and then the mixture and sulfone chloride were continuously injected into the micro-channel reactor with a metering pump at a certain proportion of flow, and the discharge temperature of the reactor was controlled at 5 ~ 10℃.
(2) Under atmospheric pressure, the reaction liquid after washing is slowly heated. When the bottom temperature of the kettle reaches 55 ° C, dichloromethane begins to steam out, and stops heating until the kettle temperature reaches 100 ° C, and the distilled solvent is collected and cooled.
(3) Under the vacuum degree of -0.1MPa, the recovered solvent is reduced pressure rectification and slowly heated. When the kettle temperature reaches 85 ~ 90℃, finished products begin to steam out. When the kettle temperature rises to 120℃, the heating is stopped and the vacuum pump is turned off to obtain qualified finished products 3-oxy-4-phenyl-ethyl butyrate.
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